Cerebrovascular Disease, Amyloid Plaques, and Dementia
نویسندگان
چکیده
منابع مشابه
Detection of amyloid plaques in patients with post-stroke dementia.
Cognitive impairment is a common sequel to stroke; the rate of post-stroke dementia is 6% to 30%. As a predictor of long-term mortality and functional disability (independent of physical impairment), post-stroke dementia poses a huge economic and social burden in developed countries. Cerebrovascular disease may not be the only factor responsible for the cognitive decline following stroke/transi...
متن کاملAtherosclerotic Plaques in the Aortic Arch and Subclinical Cerebrovascular Disease.
BACKGROUND AND PURPOSE Aortic arch plaque (AAP) is a risk factor for ischemic stroke, but its association with subclinical cerebrovascular disease is not established. We investigated the association between AAP and subclinical cerebrovascular disease in an elderly stroke-free community-based cohort. METHODS The CABL study (Cardiovascular Abnormalities and Brain Lesions) was designed to invest...
متن کاملPharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Ab amyloid deposits in vivo
Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, Royal Free Campus, University College London, Rowland Hill Street, London NW3 2PF, UK Division of Neuropathology and Department of Neurodegenerative Disease, and Stroke Research Group, Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, ...
متن کاملPharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivo.
Human amyloid deposits always contain the normal plasma protein serum amyloid P component (SAP), owing to its avid but reversible binding to all amyloid fibrils, including the amyloid β (Aβ) fibrils in the cerebral parenchyma plaques and cerebrovascular amyloid deposits of Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). SAP promotes amyloid fibril formation in vitro, contributes...
متن کاملThe Neurological Examination in Aging, Dementia and Cerebrovascular Disease
This four-part series of articles provides an overview of the neurological examination of the elderly patient, particularly as it applies to patients with cognitive impairment, dementia or cerebrovascular disease.The focus is on the method and interpretation of the bedside physical examination; the mental state and cognitive examinations are not covered in this review.Part 1 (featured in the Se...
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ژورنال
عنوان ژورنال: Stroke
سال: 2015
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.114.006571